MOST NOTEWORTHY: Genentech, Digital River and Entercom Comm were today's noteworthy downgrades:

• Jefferies downgraded Genentech (NYSE: DNA) to Hold from Buy and lowered their target to $67 from $85 following the panel vote against Avastin approval for first-line metastatic beast cancer. They believe an FDA approvable letter with request for more data is the most likely outcome on the 2/23/08 PDUFA date and lowered their estimates.
• Deutsche Bank downgraded Digital River (NASDAQ: DRIV) to Hold from Buy, as they expect shares to remain range-bound in the near-term given expectations or slower growth in 2008 and a lack of diversification away from Symantec (NASDAQ: SYMC).
• Entercom Comm (NYSE: ETM) was lowered to Market Perform from Outperform at Wachovia following a revision in the firm's long-term growth rate for radio.

OTHER DOWNGRADES:

• Wachovia downgraded the REIT office sector to Market Weight from Overweight, downgrading Corporate Office Properties (NYSE: OFC), Maguire Properties (NYSE: MPG) and Parkway Properties (NYSE: PKY) to Market Perform from Outperform.