Pfizer discontinues Phase III drug trial; stock continues to drag


Late yesterday, Pfizer (NYSE: PFE) announced the discontinuation of the SUN 1122 Phase III trial of Sutent. The drug is for treating colorectal cancer, and the study was terminated because it failed to achieve its primary end point in the study. An independent committee (the Data Monitoring Committee) found that adding sunitinib to the chemotherapy regimen FOLFIRI would be unable to demonstrate "a statistically significant improvement in the primary endpoint of progression-free survival compared to FOLFIRI alone."

The company's vice president of Clinical Development and Medical Affairs Dr. Mace Rothenberg noted, "We are disappointed with this result, but trial successes and failures are an integral part of cancer drug development and contribute to a growing body of knowledge on improving patient care."

The most common negative reactions were fatigue, asthenia, diarrhea, nausea, mucositis/stomatitis, vomiting, dyspepsia, abdominal pain, constipation, hypertension, rash, hand-foot syndrome, skin discoloration, altered taste, anorexia, bleeding, and a partridge in a pear tree. Rothenberg said that "Pfizer remains committed to developing new agents for colorectal and other GI cancers with ongoing clinical studies evaluating other agents in its pipeline."

Shares of the pharmaceutical firm have been in free-fall mode since the century turned. The stock currently faces overhead resistance from its 10-month moving average, which it has not closed above since June 2007. While this news may not be the end of the world for PFE, it isn't the kind of news a pharmaceutical company wants to hear. There is a chance for PFE to figure out what is wrong with the treatment, get it fixed and then conduct studies. My question is if someone can do this for the stock -- it sure looks like the shares could use a bit of medicine.

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Last updated: February 13, 2012: 04:50 PM

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