Today was starting out as another one of those irrational exuberance days with shares gaining, despite a Nouriel Roubini panning of the economy for a double-dip recession.

But when you factor in Meredith Whitney comments and Dick Bove calling for more bank closures, the sellers put a lid on the market. Today's last two hours were a total coin toss as to whether we'd close up or down today for the day.

Here were today's unofficial closing bell levels:

Dow 9,509.28 +3.32 (0.03%)
S&P 500 1,025.56 -0.57 (-0.06%)
Nasdaq 2,017.98 -2.92 (-0.14%)

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I had the pleasure of writing a series this spring on the Top 25 Stocks for the NEXT 25 years. I researched over 300 companies to come up with the list of what I thought were the best 25 stocks to own for the next 25 years. But something was missing that I now want to address in a new series.

The very nature of picking 25 stocks which hopefully would perform magnificently for 25 years excluded many great companies that were already executing well but could not be included because of their high current market capitalization. Some examples were "game changing" companies like Apple (NASDAQ: AAPL). Back in May, Apple had a market capitalization of about $90 billion. But I couldn't include it in my top 25 unless I expected Apple's market cap to reach several trillion dollars. I love Apple, but that's probably not in the cards. By the way, Apple today is worth $130 billion.

Another example of a game-changing company is McDonald's (NYSE: MCD). This once staid, stuck-in-the-mayonnaise company has re-invigorated itself in the past couple of years and has seen its market value more than double to $66 billion. I'd also throw in that camp Caterpillar (NYSE: CAT), which since January 2004 has seen its own market capitalization double to $51 billion. Caterpillar changed and fortified its business model starting back in late 2003. By the way, Apple,Caterpillar and McDonald's are still game changers---meaning the shares are a buy.

This begins the actual stock selections of the (hopefully) top 25 stocks for the next 25 years. These companies will play in nascent markets with a huge addressable audience and with great management and vision. They will become the leaders and game changers for the next generation of stocks.

The 25 companies are in no particular order, just random order. Keep in mind that because I am attempting to identify home runs for the more distant future, these names will be smaller capitalization names in general, or the math will not work out for investors.

The top 25 for the NEXT 25 years begins with Electro-Optical Sciences (NASDAQ: MELA).

MELA is $60 million market capitalization (total shares times by the current price) company. MELA trades at $4.50 per share and the average daily volume is about 35,000 shares per day -- not what you would call the most liquid name. But the potential and the market it will serve is massive and worldwide.

MELA is in phase III clinical trials on a device that will assist general practitioner physicians and dermatologists in the detection of melanoma, skin cancer. Typically when a physician suspects that a skin lesion or an abnormality is present, the first course of action is a biopsy. The biopsy is a bit painful and certainly expensive. There are over three million biopsies performed in the United States alone, double that amount worldwide.