MOST NOTEWORTHY:

• Genitope Corp (NASDAQ: GTOP) was downgraded to Underperform from Sector Perform at RBC Capital following MyVax's failure to meet its Phase III trial endpoint.
  
• Calyon downgraded shares of Discover Financial (NYSE: DFS) to Neutral from Buy citing the weak macro environment.
  
• Soleil downgraded Mine Safety Appliances (NYSE: MSA) to Hold from Buy at Soleil on valuation..

• Morgan Stanley downgraded Vale do Rio Doce (NYSE: RIO) to Equal Weight from Overweight.
  
• Keefe Bruyette downgraded Popular (NASDAQ: BPOP) to Underperform from Market Perform.
  
• Calyon downgraded Pride International (NYSE: PDE) to Neutral from Add.

Analyst downgrades: GTOP, DFS and MSA originally appeared on BloggingStocks on Fri, 21 Dec 2007 10:05:00 EST. Please see our terms for use of feeds.

Genitope (NASDAQ: GTOP) plans to issue a press release after 4:00 pm EST today that will discuss the initial results of its pivotal Phase 3 clinical trial examining GTOP's MyVax (personalized immunotherapy vaccine for follicular non-Hodgkin's lymphoma). GTOP is recently down $1.24 to $3.00. GTOP call option volume of 46,827 contracts compares to put volume of 6,584 contracts according to Track Data, suggesting large price risk.

Options Update is provided by Stock Specialist Paul Foster of theflyonthewall.com

Options update 12-20-07: Genitope calls spike ahead of MyVax results originally appeared on BloggingStocks on Thu, 20 Dec 2007 15:30:00 EST. Please see our terms for use of feeds.

• Bernstein initiated global pharmaceutical stocks with a Cautious view. The firm initiated Merck & Co Inc (NYSE: MRK), Schering Plough Corporation (NYSE: SGP) and Wyeth (NYSE: WYE) with Outperform ratings, as well as Bristol-Myers Squibb Company (NYSE: BMY) and Eli Lilly & Company (NYSE: LLY) with Market Perform ratings.
  
• CIBC resumed coverage of Rigel Pharmaceuticals Inc (NASDAQ: RIGL) with a Sector Outperformer rating and $16 target. The firm expects near-term upside to be driven by positive phase 2 results of R788 in rheumatoid arthritis, expected in December, and thinks the company's strong scientific platform will support long-term appreciation.
  
• Bear Stearns started Brightpoint Incorporated (NASDAQ: CELL) with an Outperform rating and $20 target, as they are positive on Brightpoint's merger with Dangaard given the significant synergies and diversification it provides.

• Genitope Corporation (NASDAQ: GTOP) was initiated with a Neutral rating at Merriman.
  
• Grubb & Ellis Company (NYSE: GBE) was reinstated with an Outperform rating at William Blair.
  
• Roth Capital started Emcore Corporation (NASDAQ: EMKR) with a Buy rating and $13.80 target.
  
• Morgan Stanley started ING Groep NV (NYSE: ING) with an Equal Weight rating.

Analyst initiations: Pharmaceutical stocks, RIGL and CELL originally appeared on BloggingStocks on Wed, 24 Oct 2007 11:30:00 EST. Please see our terms for use of feeds.

MOST NOTEWORTHY:

• Schering-Plough Corp (NYSE: SGP) was downgraded to Market Perform from Strong Buy at Raymond James, to Neutral from Overweight at HSBC and to Hold from Buy at AG Edwards on valuation.

• HSBC also cut Southwest Airlines Co (NYSE: LUV) to Neutral from Overweight.

• Capital One Financial (NYSE: COF) was cut to Market Perform from Outperform at Freidman Billings and to Neutral from Buy at Merrill Lynch following its first quarter miss.

• Stifel downgraded Robert Half International (NYSE: RHI) to Sell from Hold after its disappointing first quarter report.

• Stifel also cut Heartland Express Inc (NASDAQ: HTLD) to Hold from Buy on valuation.

• Jefferies downgraded shares of RightNow Technologies (NASDAQ: RNOW) to Hold from Buy with a $17 target. William Blair downgraded RightNow to Market Perform from Outperform based on the company's sales organization changes and weak bookings.

• Shares of CBRL Group, Inc (NASDAQ: CBRL) were downgraded at JP Morgan to Neutral from Overweight based on difficult near-term fundamentals and limited visibility.

• Baird cut HNI Corp (NYSE: HNI) to Underperform from Neutral.

• China Eastern Airlines (NYSE: CEA) was downgraded to Sell from Hold at Deutsche Bank.

• Brean Murray downgraded Genitope (NASDAQ: GTOP) to Sell from Hold.

• Sandler O'Neill downgraded shares of Capitol Bancorp Ltd (NYSE: CBC) to Sell from Hold.

Analyst downgrades 4-20-07: CBRL, COF, LUV and SGP downgraded today originally appeared on BloggingStocks on Fri, 20 Apr 2007 11:39:00 EST. Please see our terms for use of feeds.