Oprah Winfrey, arguably the most powerful woman in entertainment (if not the world in general), is preparing to pack her luxurious bags. She's announced that in 2011, after a quarter-century of favorite things and heartfelt interviews, "The Oprah Winfrey Show" will be no more. The last program is scheduled for Sept. 9, 2011. One can only imagine who might be her guests.

In syndication across the country, Oprah's eponymous program is the top-rated U.S. daytime show (take that, Days of Our Lives!), with an average viewership of 7.1 million this year.

While not entirely unexpected, the news is likely a bit of a blow to CBS Corporation (CBS), as its CBS Television Distribution arm syndicates the program. Additionally, Walt Disney (DIS) might feel the sting of an Oprah departure as Disney-owned ABC is the primary network that airs the show. And will it impact O, Oprah's monthly magazine published by the Heart Corporation? To say nothing of all of the manic women in the audience who long for a chance at one of Oprah's favorite things.

For those of you who just aren't sated by the daily one-hour program, the monthly magazine, occasional feature films and made-for-TV movies, and the radio content available at XM Satellite Radio (NASDAQ: XMSR), you'll be relieved to hear that a one-stop shop for all things Oprah is in the works.

Oprah Winfrey's privately held company, Harpo Inc., released a statement indicating that construction has started on a store carrying Oprah merchandise. The boutique will be located catty-corner from the Harpo Studios building in downtown Chicago and will be one story and 4,500 square feet. Many details, including an opening date, have yet to be worked out.

The queen of the entertainment world already sells some products through an online store. Oprah fans can pick up a $14 iPod cover with the Oprah logo, DVDs, and African apparel and artwork. The Chicago Sun-Times reports that these and other Oprah-related merchandise will also be available in the retail store. Know a co-worker or friend that's expecting? The $36 'O Baby' velour jogging suit could be the perfect gift.

Beth Gaston Moon is an analyst at Schaeffer's Investment Research.