If you are looking for clues telling you which stocks have a good chance of increasing in value, you might want consider watching where insiders are putting their money. After all, talk is cheap, but when insiders put their own money on the line, you should sit up and take note.

Biglari Holdings Inc. (BH) -- parent company of Steak 'n Shake -- topped the insider-buying charts for the week ending June 25 as insiders snapped up 27,834 shares of company stock at a market value of $8,871,287. During the past six months, insiders have increased their overall holdings in the company by 0.27% and now own 7.81% of BH stock.

Pharmacyclics Inc (PCYC) was not far behind, with insiders buying 1,075,270 shares at a market value of $7,000,008. Insiders now own 26.08% of the company's stock after decreasing their overall holdings by 0.67% during the past six months.

Analyst Upgrades

• Citigroup upgraded Baker Hughes (BHI) to hold from sell following the company's Q1 results.
• Auriga upgraded Canadian Solar (CSIQ) to buy from hold as it believes the company's negative preannouncement on April 20 removes a downside catalyst. Despite upgrading, the firm lowered its target for shares to $21 from $25.
• Deutsche Bank upgraded Post Properties (PPS) to hold from sell following the company's Q1 results. The firm upped its target for shares to $27 from $16.
• Wright Express (WXS) was upgraded to buy from neutral at Goldman.
• Nvidia (NVDA) coverage was assumed with a buy from hold at ThinkEquity.
• Elan (ELN) was upgraded to neutral from sell at UBS.

Analyst Upgrades

• Goldman upgraded Walmart (WMT) to buy from neutral, citing compelling valuation, margin expansion and expense control. The firm has a $60 target on the stock.
• FBR Capital upgraded Urban Outfitters (URBN) to outperform from market perform on valuation and its belief that sustainable positive comp trends will return in 2010. The firm maintains a $35 price target on shares.
• JPMorgan upgraded Manpower (MAN) to overweight from neutral. The firm cites valuation and improving temp fundamentals in the U.S. and France for the upgrade and has a $70 price target on the stock.
• Arena Resources (ARD) was upgraded to buy from neutral at SunTrust.
• C.R. Bard (BCR) was upgraded to neutral from underweight at Piper Jaffray.
• Cardinal Health (CAH) was upgraded to overweight from market weight at Thomas Weisel.

This was quite a week in biotechnology. You had a major premium buyout and had much data come out from the American Society of Clinical Oncology (ASCO) and others. This is far from all of the movers, but it is a brief summary of the major gainers from BioHealthInvestor.com showing how large some moves were in biotechnology this week.

Acorda Therapeutics Inc. (NASDAQ: ACOR) had a great week after it announced positive data from a second Phase III study of its Fampridine-SR for patients' walking abilities who suffer from multiple sclerosis (MS). FULL DETAILS

Auxilium Pharmaceuticals Inc. (NASDAQ: AUXL) was a strange stock this week. The company reported great news but shares slid before the market figured out it had misinterpreted news in the company. INITIAL DETAILS

Inspire Pharmaceuticals Inc. (NASDAQ: ISPH) saw a surge after it reached its primary endpoint in Phase III trial of Denufosol for Cystic Fibrosis. FULL DETAILS

Monday, December 31

• PDUFA date for Pharmacyclics (NASDAQ: PCYC)' Xcytrin for treatment of non-small cell lung cancer patients with brain metastases.

Tuesday, January 1

• Markets closed for New Year's holiday.

Wednesday, January 2

• PDUFA date for SkyePharmaceuticals (OTC: SKYEY) and Sciele Pharmaceuticals (NASDAQ: SCRX) Sular Formulation for Hypertension. The FDA extended the PDUFA Date from November 2, 2007.

Thursday, January 3

• Ford Motor Company (NYSE: F) to report monthly sales at 1pm
• General Motors (NYSE: GM) to report monthly sales at 2pm.
• AngioDynamics (NASDAQ: ANGO) to report Q2 earnings; conference call at 4:30pm.

Friday, January 4

• Millennium Pharmaceuticals (NASDAQ: MLNM) to provide guidance at 8am.
• Checkpoint Systems (NYSE: CKP) to provide guidance at 10am.
• Federal Reserve Govenor Kohn to provide keynote speech at the AEA Annual Meeting in New Orleans at 11:45am.