This was quite a week in biotechnology. You had a major premium buyout and had much data come out from the American Society of Clinical Oncology (ASCO) and others. This is far from all of the movers, but it is a brief summary of the major gainers from BioHealthInvestor.com showing how large some moves were in biotechnology this week.

Acorda Therapeutics Inc. (NASDAQ: ACOR) had a great week after it announced positive data from a second Phase III study of its Fampridine-SR for patients' walking abilities who suffer from multiple sclerosis (MS). FULL DETAILS

Auxilium Pharmaceuticals Inc. (NASDAQ: AUXL) was a strange stock this week. The company reported great news but shares slid before the market figured out it had misinterpreted news in the company. INITIAL DETAILS

Inspire Pharmaceuticals Inc. (NASDAQ: ISPH) saw a surge after it reached its primary endpoint in Phase III trial of Denufosol for Cystic Fibrosis. FULL DETAILS

MOST NOTEWORTHY: Jones Soda, Whiting Petroleum and Peregrine Pharma were today's noteworthy initiations:

• Merriman assumed coverage of Jones Soda (NASDAQ:JSDA) with a Neutral rating and believes shares will languish until interim management resets expectations. For FY08, they expect sales to grow 25%-30%, rather than the consensus estimate of 38%.
  
• Jefferies thinks Whiting Petroleum (NYSE:WLL) is entering a multi-year organic and sees catalysts from the upcoming Bakken well results and positive production response from Enhanced Oil Resources (EOR) projects. The firm started shares of Whiting with a Buy rating and $66 target.
  
• Rodman & Renshaw initiated shares of Peregrine Pharma (NASDAQ:PPHM) with a Market Perform rating, as they would prefer to establish a position closer to mid-08 when key data from its Cotara Phase II study is expected.

OTHER INITIATIONS:

• Stanford initiated Tercica (NASDAQ:TRCA) with a Buy rating and $10 target.
  
• Broadpoint initiated Pain Therapeutics (NASDAQ:PTIE) with an Underperform rating.
  
• Mattel (NYSE:MAT) was initiated with a Hold rating and $22 target at Citigroup.

Monday August 27

• Shanda Interactive Entertainment Ltd (NASDAQ: SNDA) to report Q2 earnings; conference call at 9am.
• Landstar System Inc (NASDAQ: LSTR) to hold Q3 mid-quarter conference call at 2pm.

Tuesday August 28

• Corinthian Colleges Inc (NASDAQ: COCO) to report Q4 earnings; conference call at 12pm.

Wednesday August 29

• TiVo Inc (NASDAQ: TIVO) to report Q2 earnings; conference call at 5pm.
• Novell Inc (NASDAQ: NOVL) to report Q3 earnings; conference call at 5pm.

Thursday August 30

• Freddie Mac Corp (NYSE: FRE) to report Q2 earnings; conference call at 10am.
• Novellus Systems Inc (NASDAQ: NVLS) to hold Q3 mid-quarter conference call at 4:30pm.
• PDUFA Date for Tericia Inc (NASDAQ: TRCA) for Somatuline Autogel for acromegaly.

Friday August 31

• Blyth Inc (NYSE: BTH) to hold Investor Q&A conference call at 2pm.

MOST NOTEWORTHY: EchoStar Communications Corp (DISH), PeopleSupport, Inc (PSPT), and Quicksilver, Inc (ZQK) were today's most notable downgrades:

• Credit Suisse downgraded EchoStar Communications Corp (NASDAQ: DISH) to Underperform from Neutral based on valuation and lower probability of an acquisition by AT&T (NYSE: T).

• PeopleSupport Inc (NASDAQ: PSPT) was downgraded to Market Perform from Outperform at both Piper Jaffray and Freidman Billings following disappointing Q4 earnings and guidance; JMP Securities cut PeopleSupport to Market Outperform from Strong Buy.

• Quicksilver (NYSE: ZQK) was downgraded by a host of firms: to Market Performer from Outperformer at Piper Jaffray, to Sector Performer from Outperformer at CIBC, to Hold from Buy at W.R. Hambrecht, to Neutral from Accumulate at Buckingham and to Sell from Hold at Wedbush.

OTHER DOWNGRADES:

• Freidman Billings downgraded Tercica, Inc (NASDAQ: TRCA) to Underperform from Market Perform on valuation.

• Prudential cut Cheesecake Factory Inc (NASDAQ: CAKE) to Underweight from Neutral citing soft industry sales trends which will impact Q1 and Q2 results.

• Raymond James downgraded Goldcorp Inc (NYSE: GG) to Outperform from Strong Buy.

• Lehman cut Sprint Nextel Corp (NYSE: S) to Equal-Weight from Overweight.

• UBS downgraded New Century Financial Corp (NYSE: NEW) to Reduce from Neutral.

• Stifel downgraded C.H. Robinson Worldwide, Inc (NASDAQ: CHRW) to Sell from Hold.

Analyst summaries provided by TheFlyOnTheWall.com (subscription required).

MOST NOTEWORTHY: Campbell Soup Company (CPB) and Wyerhaeuser Company (WY) topped today's modest-sized list of downgrades:

• Goldman Sachs downgraded Campbell Soup Co (NYSE: CPB) to Sell from Neutral with a $40 target and added the company to its America's Sell List as they see minimal upside over the next year.

• UBS cut Wyerhaeuser Co (NYSE: WY) to Reduce from Neutral on valuation.

OTHER DOWNGRADES:

• Cooper Tire & Rubber Company (NYSE: CTB) was downgraded at Deutsche Bank to Hold from Buy on valuation.

• Progressive Gaming International Corp (NASDAQ: PGIC) was cut to Accumulate from Buy at ThinkEquity.

• Lazard downgraded Insmed Inc (NASDAQ: INSM) to Hold from Buy following the litigation settlement with Tercica, Inc (NASDAQ: TRCA) as they see a lack of revenues for the next 2-3 years

Analyst summaries provided by TheFlyOnTheWall.com (subscription required).