Oprah Winfrey, arguably the most powerful woman in entertainment (if not the world in general), is preparing to pack her luxurious bags. She's announced that in 2011, after a quarter-century of favorite things and heartfelt interviews, "The Oprah Winfrey Show" will be no more. The last program is scheduled for Sept. 9, 2011. One can only imagine who might be her guests.

In syndication across the country, Oprah's eponymous program is the top-rated U.S. daytime show (take that, Days of Our Lives!), with an average viewership of 7.1 million this year.

While not entirely unexpected, the news is likely a bit of a blow to CBS Corporation (CBS), as its CBS Television Distribution arm syndicates the program. Additionally, Walt Disney (DIS) might feel the sting of an Oprah departure as Disney-owned ABC is the primary network that airs the show. And will it impact O, Oprah's monthly magazine published by the Heart Corporation? To say nothing of all of the manic women in the audience who long for a chance at one of Oprah's favorite things.