It wasn't all that long ago that Microsoft Corporation (NASDAQ: MSFT) eyed Yahoo, Inc. (NYSE: YHOO) with an eye towards acquisition. Yahoo fought it off, spending a great deal of money and lawyer's time, and filling any tech-oriented new outlets with headlines for quite a while.

Now the smell of acquisition is once more in the air thanks to Microsoft honcho Steve Ballmer saying a deal would "make sense." Yahoo is even cheaper than the $19/share level that first got Microsoft interested. In a shaky economy, giants like Microsoft can afford to go hunting for small companies to snap up.

Now this is so far just an off-hand statement (in appearance). Ballmer could just be testing the waters to see how Yahoo! and its shareholders react. So far today, the market reacted by bidding the share price of Yahoo up.

Another year, another round of Yahoo! Inc. (NASDAQ: YHOO) acquisition chatter. But would any company really want to acquire Yahoo? A market cap of over $33 billion should be enough to give any company pause, and with its growth rate and profitability teetering along at the age-old web giant, the price of admission is probably too high. Forget Microsoft (NASDAQ: MSFT) -- that would be the worst mistake the software company could make. Anyone else? A show of hands please?

Jerry Yang, now the company's CEO, and David Filo desperately want a turnaround at the company they founded. Once the highest flier on the web scene, Yahoo! has been dragged down by the rapid ascension of Google (NASDAQ: GOOG).

Yahoo!, which still has a lot to offer, made a bad bet on its version of text advertising while Google walked off into the sunset with a formula that worked. Add that to former CEO Terry Semel's apparent incompetence in trying to balance paid services against comparable free services from the competition, and you get a company that is in a funk right now.

Most likely, Yahoo! will not be acquired by another company, although it will continue to ring up partnerships to enhance its bottom line. Still, the core functionality of the company is at stake here, and there's miles of work to be done in 2008 -- which will be a make or break year. Even at $10 billion, it's hard to fathom who would want to purchase Yahoo! That means the company is in it for the long haul, and the competition from Microsoft and Google will only get hotter from here.

As Melly Alazraki mentioned in her post last night, everyone is mourning, alas poor Yahoo!: the real loser in the Google-YouTube deal. And the best defense is a good offense, right? So naturally the lips of investment bankers are wet with the licking. I can just see (in my imagination silly! I don't have spies) the acquisition pitchbooks being pitched left and right all over Terry Semel's desk.

Is Yahoo! Inc. (NASDAQ:YHOO) buying? And if the company is keeping its fax machines busy with term sheets, who might it buy?

Yahoo!'s never been afraid of a good little acquisition. Hello, Flickr, hello, Facebook.com? Interested parties have mentioned names like Dabble (a sort of online TV Guide, and no, I never heard of it either), Heavy.com (whose co-CEO says that, although he's not selling, he'd of course consider a deal with "a good exit strategy," haha) and our own Tom Taulli's favorite, vMix, whose CEO spoke not a word of acquisition talk in his interview with us.

But Melly makes an excellent point: shouldn't Yahoo! finish Project Panama first? How the heck could the company even monetize an acquisition right now? Maybe eBay should be the one out there buying. Yeah!

I can just hear the investment bankers scurrying back to their PowerPoint files now and doing replace-all for "synergies with" from "Flickr" to "Skype" ...